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MYP_118055
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Basic Information
PaDef defensin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
47 amino acids
C210H341N73O64S9
Standard
Sequence
ATCETPSKHFNGLCIRSSNCASVCHGEHFTDGRCQGVRRRCMCLKPC
Physicochemical Analysis
5200.99 Da
8.77
3.98
3.52
0.0847
-0.41
0.41
-0.17
49.42
41.49
0.0426
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2214.70
-30.79
87.0
80.0
170.0
356.0
7.0
49.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0030753 VERIFIED: YES
Provenance & Taxonomy
Persea americana var. drymifolia [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic Pro-apoptotic Extrinsic apoptosis
K562 chronic myeloid leukemia cells
97.3 μg/mL
IC50; cell viability assay; apoptosis assay
PaperPaDef defensin from avocado (Persea americana var. drymifolia) is cytotoxic to K562 chronic myeloid leukemia cells through extrinsic apoptosis. Int J Biochem Cell Biol. 2018. DOI:10.1016/j.biocel.2018.03.013; PMID:29559362 PMID29559362 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27470405/
RECORD: Rec_0204729 VERIFIED: YES
Provenance & Taxonomy
Persea americana var. drymifolia [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic Pro-apoptotic Intrinsic apoptosis
MCF-7 human breast cancer cells
141.62 μg/mL
IC50; cell viability assay; apoptosis assay
PaperPubMed PMID: 27470405 PMID27470405 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27470405/
RECORD: Rec_0212535 VERIFIED: YES
Provenance & Taxonomy
Persea americana var. drymifolia [Plant]
Defensin
Structure & Mods
disulfide-stabilized linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-47; 14-34; 20-41; 24-43
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer
Escherichia coli; Staphylococcus aureus; MCF-7 human breast cancer cells
Qualitative antibacterial growth inhibition; cell viability assay; apoptosis assay
PaperAntibacterial activity of the defensin PaDef from avocado fruit. PMID:24319695; A defensin from avocado induces apoptosis in MCF-7 cells. PMID:27470405 PMID24319695;27470405
RECORD: Rec_0238849 VERIFIED: YES
Provenance & Taxonomy
Persea americana var. drymifolia [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic Pro-apoptotic Intrinsic apoptosis Extrinsic apoptosis
MCF-7 human breast cancer cells; K562 chronic myeloid leukemia cells
Cell viability assay; IC50; apoptosis assay
PaperPubMed PMID: 27470405 PMID27470405;29559362 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27470405/
RECORD: Rec_0310751 VERIFIED: NO
Provenance & Taxonomy
Persea americana var. drymifolia [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
PaperPubMed PMID: 27470405 PMID27470405 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27470405/