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MYP_118030
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Basic Information
PGLa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C88H161N25O23S
Standard
Sequence
GMASKAGAIAGKIAKVALKAL
Physicochemical Analysis
1969.44 Da
10.48
3.76
3.55
0.1789
0.84
0.60
0.30
-4.81
121.43
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
769.63
-6.77
27.0
28.0
70.0
137.0
0.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0265961 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0268419 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus 29213
125-500 μg/mL
MIC
PMID3606567;1717472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3606567/
RECORD: Rec_0270488 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
PGla
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum
40 μM
IC50; Microscopy (Acridine orange staining)
PaperAntimicrobial peptide action on parasites PMID22664071 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22664071/
RECORD: Rec_0273689 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
Clavibacter michiganensis
1.15-2.3 μM
MIC
PaperAntimicrobial properties of peptides from Xenopus granular gland secretions. PMID3125066
RECORD: Rec_0281427 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
PGLa
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiparasitic
Human erythrocytes
200 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/3125066/ PMID3125066 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3125066/
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