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MYP_118030
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Basic Information
PGLa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C88H161N25O23S
Standard
Sequence
GMASKAGAIAGKIAKVALKAL
Physicochemical Analysis
1969.44 Da
10.48
3.76
3.55
0.1789
0.84
0.60
0.30
-4.81
121.43
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
769.63
-6.77
27.0
28.0
70.0
137.0
0.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0365148 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa 27853
250-500 μg/mL
MIC
PMID3606567;1717472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3606567/
RECORD: Rec_0379551 VERIFIED: NO
Provenance & Taxonomy
Xenopus laevis [Animal]
PGLa
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
900.0 μM
HC50
PaperPhD disertation (page 48) of Carsten Sachse (2003), Friedrich-Schiller-University Jena. F-Festkoerper-NMR-Untersuchungen zur Orientierung und Dynamik des antimikrobiellen Peptids PGLa in Lipidmembranen Evidence URLhttps://www.uniprot.org/uniprotkb/Q99134/entry
RECORD: Rec_0383123 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
Staphylococcus aureus ATCC 25923; methicillin-resistant Staphylococcus aureus (MRSA)
25-50 μM
MIC
PaperAntimicrobial properties of peptides from Xenopus granular gland secretions. PMID3125066
RECORD: Rec_0387403 VERIFIED: NO
Provenance & Taxonomy
Xenopus laevis [Animal]
PGLa
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
PaperF. Hou et al. / International Journal of Antimicrobial Agents 38 (2011) 510-515. Isolation and characterisation of a new antimicrobial peptide from the skin of Xenopus laevis PMID22014884 Evidence URLhttps://www.uniprot.org/uniprotkb/Q91826/entry
RECORD: Rec_0398967 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | CEM-SS cells
50.8 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. | Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. | DOI:10.1128/AAC.01448-09 | PMID:20086159 PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
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