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MYP_118030
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Basic Information
PGLa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C88H161N25O23S
Standard
Sequence
GMASKAGAIAGKIAKVALKAL
Physicochemical Analysis
1969.44 Da
10.48
3.76
3.55
0.1789
0.84
0.60
0.30
-4.81
121.43
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
769.63
-6.77
27.0
28.0
70.0
137.0
0.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0312990 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus 29213
125-500 μg/mL
MIC
PMID1717472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1717472/
RECORD: Rec_0316092 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli 25922
62-125 μg/mL
MIC
PMID3606567;1717472 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3606567/
RECORD: Rec_0338355 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
Saccharomyces cerevisiae ATCC A3180, and Candida albicans
100-200 μg/mL
MIC
PaperAntimicrobial properties of peptides from Xenopus granular gland secretions.
RECORD: Rec_0344448 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-CCV Entry inhibition
Channel Catfish virus (CCV)
100 μM
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides. | Chinchar VG, Bryan L, Silphadaung U, Noga E, Wade D, Rollins-Smith L. | Virology. 2004 Jun 1;323(2):268-75. | DOI:10.1016/j.virol.2004.02.029 | PMID:15193922 PMID15193922 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15193922/
RECORD: Rec_0345659 VERIFIED: YES
Provenance & Taxonomy
Xenopus laevis [Animal]
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiparasitic
c, Streptococcus pyogenes ATCC 19615
10-50 μg/mL
MIC
PaperAntimicrobial properties of peptides from Xenopus granular gland secretions.
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