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MYP_118021
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Basic Information
HsAp1
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C143H239N43O41S
Standard
Sequence
SGTSEKERESGRLLGVVKRLIVCFRSPFP
Physicochemical Analysis
3248.76 Da
10.04
2.46
2.23
0.0847
-0.28
0.70
-0.14
70.92
83.79
0.0690
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1373.23
-14.30
51.0
45.0
109.0
228.0
4.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0240775 VERIFIED: YES
Provenance & Taxonomy
Heterometrus spinifer [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
Klebsiella oxytoca AB 2010143
50.5 μM
MIC
PMID23000095 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23000095/
RECORD: Rec_0289008 VERIFIED: YES
Provenance & Taxonomy
Heterometrus spinifer [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0303259 VERIFIED: YES
Provenance & Taxonomy
Heterometrus spinifer [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida tropicalis AY 91009
48.6 μM
MIC
PMID23000095 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23000095/
RECORD: Rec_0319270 VERIFIED: YES
Provenance & Taxonomy
Insecta [Animal]; Arthropoda [Animal]
50557; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID16940129 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16940129/
RECORD: Rec_0332435 VERIFIED: YES
Provenance & Taxonomy
Heterometrus spinifer [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Gram-positive bacteria B. magaterium AB 90008
11.8 μM
MIC
PaperA novel class of antimicrobial peptides from the scorpion Heterometrus spinifer.
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