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MYP_117992
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Basic Information
Ocellatin-3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C98H168N28O29
Standard
Sequence
GVLDILKNAAKNILAHAAEQI
Physicochemical Analysis
2202.55 Da
6.75
-0.15
-0.41
-0.0072
0.44
0.67
0.22
49.88
149.05
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
929.91
-7.66
30.0
30.0
76.0
155.0
1.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0225066 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0233807 VERIFIED: NO
Provenance & Taxonomy
Leptodactylus ocellatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic
Human erythrocytes
RECORD: Rec_0276857 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus ocellatus [Animal]
Ocellatin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Has hemolytic activity against human erythrocytes
Hemolysis
PMID15648972 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15648972/
RECORD: Rec_0277392 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus bolivianus [Animal]
Ocellatin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
PaperA. Nascimento et al. / Toxicon 50 (2007) 1095-1104. Purification, characterization and homology analysis of ocellatin 4, a cytolytic peptide from the skin secretion of the frog Leptodactylus ocellatus Evidence URLhttps://www.uniprot.org/uniprotkb/P83867/entry
RECORD: Rec_0393065 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus ocellatus [Animal]
Frog skin active peptide (FSAP); Ocellatin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Cytolytic Hemolytic
Gram-negative bacteria
PMID15648972 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15648972/
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