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MYP_117970
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Basic Information
Oncocin Onc112 [K3R], Onc246
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
19 amino acids
C109H176N38O25
Standard
Sequence
VDRPPYLPRPRPPRRIYNR
Physicochemical Analysis
2418.80 Da
11.71
4.73
4.52
0.2491
-1.77
0.56
-0.64
76.66
56.32
0.1053
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1026.63
-8.26
36.0
30.0
68.0
172.0
8.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0208611 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa DSM1117
64 μg/mL
MIC
PMID34902208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34902208/
RECORD: Rec_0327533 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperEffect of Amino Acid Substitutions on 70S Ribosomal Binding, Cellular Uptake, and Antimicrobial Activity of Oncocin Onc112. Chembiochem. 2022 Mar 4;23(5):e202100609. doi: 10.1002/cbic.202100609. PMID: 34902208. PMID34902208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34902208/
RECORD: Rec_0343134 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli MC4100
8 μg/mL
MIC
PMID34902208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34902208/
RECORD: Rec_0398423 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: HepG2 (46% Killing=600 μg/ml)
PaperEffect of Amino Acid Substitutions on 70S Ribosomal Binding, Cellular Uptake, and Antimicrobial Activity of Oncocin Onc112. Chembiochem. 2022 Mar 4;23(5):e202100609. doi: 10.1002/cbic.202100609. PMID: 34902208. PMID34902208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34902208/
RECORD: Rec_0420651 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae DSM681
8 μg/mL
MIC
PMID34902208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34902208/
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