Peptide Database

Peptide NameUnnamed

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ CaMKII Inhibitory

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC63H113N21O20

DescriptionStandard

        KKALRRDEAVDAL
    

Molecular Weight1484.70 Da

Isoelectric Point (pI)8.59

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0587

GRAVY Index-0.78

Hydrophobic Moment 0.39

Boman Index-0.43

Instability Index56.55

Aliphatic Index 105.38

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 700.26

LogP -6.38

H-bond Donors 25.0

H-bond Acceptors 21.0

Rotatable Bonds 53.0

Heavy Atoms 104.0

Ring Count 0.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0228954 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAIP

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

CaMKII Inhibitory

TargetCalmodulin-dependent protein kinase II (CaMKII)

Activity5.1 μM

MethodIC50

PaperIshida A., Shigeri Y., Tatsu Y., Uegaki K., Kameshita I., Okuno S., Kitani T., Yumoto N., Fujisawa H.. Critical amino acid residues of AIP, a highly specific inhibitory peptide of calmodulin-dependent protein kinase II. FEBS Lett.,427,115-118 (1998). PMID9613610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9613610/