Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length480 amino acids

Chemical FormulaC2423H3806N656O683S12

DescriptionStandard

        RPYCVVVALLLLAEVSRLGEGASNPGFVVRITRKGLEYARQYGMATLKKELSTINVPDLSGSFEVGWMGSVSYEFKSLRIRSFQIRNSDLSLLPGRGVRASLSNNYVSISGNWKVKKAFIGKKRGTFDLSVDGVSISIYLNLGEDGTGRPTASVAHCSNSVGHVSIHVSGNLSWILNLFHRRIENKLKDILKQEIWEIVRTSTSSHLEPYLRTLPVTLMIDQVAGIDYSLVGAPQVTSQGLDTPFKGEFFGRSQRSPVPFDAPPIRLPQQHDRMAYFAVSQYVFNTASRVYHQAGHMNFTIRNEDSPLDFPIHLHTKSLGAVIPQLARLYPNTELELEMSPESAPFLMFTPGNVTCMPVMNIQAFALLPNSSNRKPLFQLRARTDISATISVSSGRVHGSLTPGSKLKLELKHSNIGFFNVQLLESIFNYYASYIIYPSLNAKFEKGFPLPLPRDTYLNSLELQVHKPKVLVSALIGFLF
    

Molecular Weight53438.90 Da

Isoelectric Point (pI)9.57

Net Charge (pH 7.0)14.90

Net Charge (pH 7.4) 13.89

Charge Density (pH 7.0) 0.0310

GRAVY Index-0.06

Hydrophobic Moment 0.84

Boman Index0.08

Instability Index38.80

Aliphatic Index 95.42

Aromaticity 0.0979

Extinction Coeff. Reduced 47330.00

Extinction Coeff. Oxidized 47455.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0198136 VERIFIED: NO

Provenance & Taxonomy

OrganismMyotis lucifugus [Animal]

FamilyBPI/LBP

Tax ID59463

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence