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MYP_117884
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Basic Information
ES-43
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Cardiovascular
Hormonal / Endocrine ▸ Hormone peptide
Hormonal / Endocrine ▸ Secretory pathway peptide ▸ Secretory granule peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
33 amino acids
C152H230N36O67
Standard
Sequence
EEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSL
Physicochemical Analysis
3633.65 Da
4.05
-15.04
-15.28
-0.4557
-1.28
0.34
-0.12
131.27
59.09
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1631.09
-16.49
49.0
53.0
119.0
255.0
5.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0248454 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ES
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
24:O-linked (GalNAc...) threonine
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Antibacterial Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Metabolic regulation Physiological regulation Myotropic Receptor modulation Immunomodulatory
cells and noradrenergic neurons
Mammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for ES-43 (Homo sapiens): PMID 15326220,12442257 PMID15326220;12442257 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15326220/
RECORD: Rec_0280878 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ES
9606
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
24:O-linked (GalNAc...) threonine
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Antibacterial Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Metabolic regulation Physiological regulation Myotropic Receptor modulation Immunomodulatory
Mammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for ES-43 (Homo sapiens): PMID 24723458,12442257 PMID24723458;12442257 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24723458/
RECORD: Rec_0329525 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0347219 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0422865 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Chromogranin/secretogranin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Secretory granule peptide Neuropeptide precursor
Evidence URLhttps://www.uniprot.org/uniprotkb/CMGA_HUMAN/entry