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MYP_117876
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Basic Information
LL-III
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
15 amino acids
C86H152N22O17
Standard
Sequence
VNWKKILGKIIKVVK
Physicochemical Analysis
1766.26 Da
10.60
4.73
4.51
0.3153
0.37
0.75
0.10
-14.96
162.00
0.0667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
659.70
-0.79
23.0
22.0
64.0
125.0
2.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0379579 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
LL-III
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 6 and 10) indicates 2-(4'-pentenyl) alanine in the S configuration. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus
0.7 μM
MIC
PaperHubert Chapuis, Jiřina Slaninová, Lucie Bednárová, Lenka Monincová, Miloš Buděšínský, Václav Čeřovský. Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera. Amino Acids. 2012 Nov;43(5):2047-58. Epub 2012 Apr 18. PMID22526241 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526241/
RECORD: Rec_0385940 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
LL-III
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
trans-conformation L-amino-acid peptide [Modified]
None
Amidation
The Ⓩ (position: 3) indicates 2-(7'-octenyl) alanine in the R configuration. The Ⓧ (position: 10) is 2-(4'-pentenyl) alanine in the S configuration. Ⓩ (3) and Ⓧ (10) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
5.5 μM
MIC
PaperHubert Chapuis, Jiřina Slaninová, Lucie Bednárová, Lenka Monincová, Miloš Buděšínský, Václav Čeřovský. Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera. Amino Acids. 2012 Nov;43(5):2047-58. Epub 2012 Apr 23. PMID22526241 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526241/
RECORD: Rec_0395366 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Lasioglossin III
88510.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial Antifungal
HepG-2 (liver cancer)
7.75 μM
IC50
PaperToxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells | https://pubmed.ncbi.nlm.nih.gov/22100226/ PMID22100226 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100226/
RECORD: Rec_0404119 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
LL-III
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 2 and 6) indicates 2-(4'-pentenyl) alanine in the S configuration. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
1.2 μM
MIC
PaperHubert Chapuis, Jiřina Slaninová, Lucie Bednárová, Lenka Monincová, Miloš Buděšínský, Václav Čeřovský. Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera. Amino Acids. 2012 Nov;43(5):2047-58. Epub 2012 Apr 20. PMID22526241 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526241/
RECORD: Rec_0406274 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans ATCC 10231
25 μM
MIC
PMID30753486 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30753486/
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