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MYP_117876
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Basic Information
LL-III
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
15 amino acids
C86H152N22O17
Standard
Sequence
VNWKKILGKIIKVVK
Physicochemical Analysis
1766.26 Da
10.60
4.73
4.51
0.3153
0.37
0.75
0.10
-14.96
162.00
0.0667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
659.70
-0.79
23.0
22.0
64.0
125.0
2.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0305594 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
LL-III
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
trans-conformation L-amino-acid peptide [Modified]
None
Amidation
The Ⓩ (position: 3) indicates 2-(7'-octenyl) alanine in the R configuration. The Ⓧ (position: 10) is 2-(4'-pentenyl) alanine in the S configuration. Ⓩ (3) and Ⓧ (10) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis
1.3 μM
MIC
PaperHubert Chapuis, Jiřina Slaninová, Lucie Bednárová, Lenka Monincová, Miloš Buděšínský, Václav Čeřovský. Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera. Amino Acids. 2012 Nov;43(5):2047-58. Epub 2012 Apr 23. PMID22526241 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526241/
RECORD: Rec_0307741 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Lasioglossum laticeps [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Escherichia coli
1.4 μM
MIC
PaperLasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial Bee Lasioglossum laticeps (Hymenoptera: Halictidae).
RECORD: Rec_0307782 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans ATCC MYA-2876
6.3 μM
MIC
PMID30753486 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30753486/
RECORD: Rec_0311915 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
3.9 μM
MIC
PMID19591185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19591185/
RECORD: Rec_0312649 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
1.4 μM
MIC
PMID19591185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19591185/
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