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MYP_117835
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Basic Information
Amphiphatic peptide CT1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C72H106N16O16
Standard
Sequence
FLGALWNVAKSVF
Physicochemical Analysis
1451.71 Da
8.75
0.76
0.55
0.0584
1.21
0.45
0.52
30.41
120.00
0.2308
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
517.65
-1.50
18.0
17.0
44.0
104.0
4.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0148551 VERIFIED: YES
Provenance & Taxonomy
Vaejovis mexicanus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
25 μM
MIC
RECORD: Rec_0151092 VERIFIED: YES
Provenance & Taxonomy
Vaejovis mexicanus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Candida albicans MDM8
12.5 μM
MIC
PaperNovel designed VmCT1 analogs with increased antimicrobial activity. Eur J Med Chem. 2017 Jan 27;126:456-463. doi: 10.1016/j.ejmech.2016.11.040. PMID: 27912176. PMID27912176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27912176/
RECORD: Rec_0157645 VERIFIED: YES
Provenance & Taxonomy
Vaejovis mexicanus smithi [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
10 μM
MIC
PMID22342498;31212183;33442881;31181304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22342498/
RECORD: Rec_0158776 VERIFIED: YES
Provenance & Taxonomy
Vaejovis mexicanus smithi [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Plasmodium gallinaceum
8.3 ± 1.4
IC50
PMID22342498;31212183;33442881;31181304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22342498/
RECORD: Rec_0162281 VERIFIED: YES
Provenance & Taxonomy
Vaejovis mexicanus smithi [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic Antiprotozoal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
25 μM
MIC
PMID22342498;31212183;33442881;31181304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22342498/
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