Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length136 amino acids

Chemical FormulaC656H1038N178O201S7

DescriptionStandard

        MFKGSMLGPIHDAFSQQLCPQFDRSVVQMETLLNSLPVTEPVDSVAALELSLVSPPLITEQNVDLLVRGQFVGLSQRWDVPYSPVEMDLPDAESRMLVLAVSQFSANSASYVHYKSGALRANITDDMVRRGGHGPA
    

Molecular Weight14858.79 Da

Isoelectric Point (pI)4.81

Net Charge (pH 7.0)-6.23

Net Charge (pH 7.4) -6.63

Charge Density (pH 7.0) -0.0458

GRAVY Index0.01

Hydrophobic Moment 0.60

Boman Index0.10

Instability Index57.79

Aliphatic Index 93.82

Aromaticity 0.0662

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6012.73

LogP -61.40

H-bond Donors 204.0

H-bond Acceptors 205.0

Rotatable Bonds 480.0

Heavy Atoms 1042.0

Ring Count 23.0

Amide Bonds 147.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0268014 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria