Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length458 amino acids

Chemical FormulaC2281H3659N591O656S20

DescriptionStandard

        MVSFTQCCCQLASRQFKHPDRKRPSIGTSQQFKIIVLEMMFLWCVLVLVNLVSVATDTNAGVKVRLTQKGLEYGRQIAIASIQQKLRTIQLQDISGTERVKAVGKVQYSFTGRNSGSFDLSVNELTISTTIVITSDNTGRPMVSVKTCAATVGSVKVKFHGGASWLYNLFRSFINKALRNALQKKICPLVIRSIADTNPHLKTLNGDMINYVLITVLAKVDQYAEIEYSMVGSPVISNTFIDLGLKGEFYNIGQHKEPPFSPKPFSLPTQDTKMLYFGISAFSINSAGFVYQTAGVLRLSITDDMIETMYPDLMVKLLVETVKEPLVTFEPNNMTVQASSTVTAYAIQPNSTLSPLFVLNLEGSVSAHMYVTELKLAGNVTLNKFKMSVAESYVGPFQVGSLDKIFTVVLRVAVLPLVNARLQEGFPLPAIGKMQLVNSQLQVLKDYLLIGTDVQFNG
    

Molecular Weight50499.32 Da

Isoelectric Point (pI)9.24

Net Charge (pH 7.0)10.90

Net Charge (pH 7.4) 10.24

Charge Density (pH 7.0) 0.0238

GRAVY Index0.18

Hydrophobic Moment 0.74

Boman Index0.14

Instability Index30.91

Aliphatic Index 102.49

Aromaticity 0.0852

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 32235.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0359893 VERIFIED: NO

Provenance & Taxonomy

OrganismLabeo rohita [Bacterium]

FamilyBPI

Tax ID84645

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence