Peptide Database

Peptide NameSLAY-screened peptide P2277

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC86H140N26O35

DescriptionStandard

        SRRIDYESNSEEAQVITT
    

Molecular Weight2098.18 Da

Isoelectric Point (pI)4.41

Net Charge (pH 7.0)-2.53

Net Charge (pH 7.4) -2.75

Charge Density (pH 7.0) -0.1406

GRAVY Index-1.12

Hydrophobic Moment 0.33

Boman Index-0.32

Instability Index83.10

Aliphatic Index 65.00

Aromaticity 0.0556

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1038.58

LogP -14.17

H-bond Donors 37.0

H-bond Acceptors 33.0

Rotatable Bonds 71.0

Heavy Atoms 147.0

Ring Count 1.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0198253 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/