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MYP_117707
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Basic Information
Gramicidin S, GS
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
10 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VXLFPVXLFP
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0272376 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 2,7
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Acinetobacter calcoaceticus DSM 586
16 μg/mL
MIC
PMID16434018;19528287;10224074;8810288;15981419;19132829;24752256;17462586;27328781;22976321;20951594 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16434018/
RECORD: Rec_0277587 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Ornithine
Bio-Activity Profile
Antimicrobial
Human erythrocytes
12.5 μg/mL
MHC
Paperhttps://pubmed.ncbi.nlm.nih.gov/18568863/ PMID18568863 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18568863/
RECORD: Rec_0278577 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Peptide antibiotic
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
Ornithine (O)
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum 3D7
1.3 μM
IC50; PLDH assay
PMID17462586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17462586/
RECORD: Rec_0283030 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 2,7
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Bacillus subtilis 168
1.3 μM
MIC
PMID16434018;19528287;10224074;8810288;15981419;19132829;24752256;17462586;27328781;22976321;20951594 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16434018/
RECORD: Rec_0284453 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Contains X placeholder residue(s)
Bio-Activity Profile
Antimicrobial
PaperPatent US 6358921 B1 Evidence URLhttps://patents.google.com/patent/US6358921B1/en PatentUS 6358921 B1
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