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MYP_117707
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Basic Information
Gramicidin S, GS
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
10 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VXLFPVXLFP
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0211284 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
X=Orn; f=D-Phe
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
7.4 μM
LC50
PaperPubMed PMID: 17462586 PMID17462586 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17462586/
RECORD: Rec_0220750 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
No specific N-terminal
No specific C-terminal
The 'O' in sequence is Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus cereus CIP 66
PMID29499484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29499484/
RECORD: Rec_0224895 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
Ornithine
Bio-Activity Profile
Antimicrobial Hemolytic
Human erythrocytes
12.5 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/10224074/ PMID10224074 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10224074/
RECORD: Rec_0227990 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
No specific N-terminal
No specific C-terminal
The 'O' in sequence is Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa CIP 82
PMID29499484 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29499484/
RECORD: Rec_0243046 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 2,7
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Bacillus subtilis DSM 347
02-4 μg/mL
MIC
PMID16434018;19528287;10224074;8810288;15981419;19132829;24752256;17462586;27328781;22976321;20951594 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16434018/
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