Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length541 amino acids

Chemical FormulaC2646H4257N747O749S23

DescriptionStandard

        MGMQSVAVACGALALCLALTTATNPGFVVRMTQAGLDYAQQQGMAILEKELAQLKLPDISGKSGKVRYELSRLRITSFRLPHSRITPISNVGLEVSISNSFAELNGDWRVKFLFIRDHGSFNLKVENVYMKIVLRLGSDTTGKPTISTSDCSASISKVRVRFSGKLGWLYNLFHSVIESKLRKSLERKVCDNVAKSVQNELQKQIQTLPVTARIDDKIGIDYSLVAPPRATAQSLDADLKGEFYSLAHRSTAPFSPLPLAFPPGSRAHASSYFFNTAGIAYHKAGALVFEITEAMVSGRSRTKMGKRFHLLRCSRSSQQSWRSPNKRAEGCGMGLGCQTWQHLGTGGLAMGSSVPHCPRVTVLSLQIPKKAGFSLDTSAFSAFIPQLEEMYPNMPMKFRLSTPTAPFLTIGPGGISFQPIVDAQAYAILPNSSLAPLFLLSLTGNVSAVINVRSGRIVGSLDVGRIRLSLKDSAVGHFQLRMMQSLMNILTSNTLLPRLNARLDEGFPLPLLDRIQLSNILVRFHQNFLLLGADIRFQPRG
    

Molecular Weight59255.16 Da

Isoelectric Point (pI)10.04

Net Charge (pH 7.0)27.41

Net Charge (pH 7.4) 26.43

Charge Density (pH 7.0) 0.0507

GRAVY Index0.01

Hydrophobic Moment 0.71

Boman Index0.06

Instability Index38.13

Aliphatic Index 94.84

Aromaticity 0.0758

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37400.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0123780 VERIFIED: NO

Provenance & Taxonomy

OrganismChloebia gouldiae [Bacterium]

FamilyBPI

Tax ID44316

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence