Peptide Database

Peptide NameAntimicrobial peptide THP1 (Turkey heterophil peptide 1)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length65 amino acids

Chemical FormulaC319H527N87O80S7

DescriptionStandard

        MRIVYLLFPFILLLAQGAAGSSLALGKREKCLRRNGFCAFLKCPTLSVISGTCSRFQVCCKTLLG
    

Molecular Weight7085.59 Da

Isoelectric Point (pI)9.77

Net Charge (pH 7.0)7.44

Net Charge (pH 7.4) 7.13

Charge Density (pH 7.0) 0.1144

GRAVY Index0.72

Hydrophobic Moment 0.51

Boman Index0.18

Instability Index36.95

Aliphatic Index 111.08

Aromaticity 0.0923

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2670.36

LogP -22.31

H-bond Donors 102.0

H-bond Acceptors 95.0

Rotatable Bonds 236.0

Heavy Atoms 493.0

Ring Count 8.0

Amide Bonds 67.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0316567 VERIFIED: YES

Provenance & Taxonomy

OrganismMeleagris gallopavo [other]

FamilyBeta-defensin; Defensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus