Peptide Database

Peptide NameDefensin 4, MtDef4

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC215H339N79O66S8

DescriptionStandard

        RTCESQSHKFKGPCASDHNCASVCQTERFSGGRCRGFRRRCFCTTHC
    

Molecular Weight5343.00 Da

Isoelectric Point (pI)9.17

Net Charge (pH 7.0)5.95

Net Charge (pH 7.4) 5.47

Charge Density (pH 7.0) 0.1265

GRAVY Index-0.87

Hydrophobic Moment 0.47

Boman Index-0.35

Instability Index64.81

Aliphatic Index 10.43

Aromaticity 0.0851

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2387.75

LogP -36.07

H-bond Donors 96.0

H-bond Acceptors 83.0

Rotatable Bonds 176.0

Heavy Atoms 368.0

Ring Count 8.0

Amide Bonds 49.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0167994 VERIFIED: YES

Provenance & Taxonomy

OrganismMedicago truncatula [Plant]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetFusarium oxysporum f. sp. medicaginis 7F-3

Activity0.7

MethodIC50

RECORD: Rec_0195052 VERIFIED: YES

Provenance & Taxonomy

OrganismMedicago truncatula [Plant]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetColletotrichum trifolii WS-5

RECORD: Rec_0221532 VERIFIED: YES

Provenance & Taxonomy

OrganismMedicago truncatula [Plant]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetAphanomyces euteiches MER4

RECORD: Rec_0256291 VERIFIED: YES

Provenance & Taxonomy

OrganismMedicago truncatula [Plant]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetClavibacter michiganensis subsp. insidiosus

Activity0.1

MethodIC50

RECORD: Rec_0283569 VERIFIED: YES

Provenance & Taxonomy

OrganismMedicago truncatula [Plant]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetFusarium graminearum

Activity1.5-2.5 μM

MethodMIC

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