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MYP_117590
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Basic Information
Dermaseptin-S1 (1-15)[W3HPA]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
15 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
ALXKTMLKKLGTMAL
Physicochemical Analysis
0.00 Da
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0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0267213 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 3
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans
5.8 μM
MIC
PMID18676150;20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18676150/
RECORD: Rec_0287003 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 3
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus Cowan 1
2.4 μM
LD50
PMID18676150;20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18676150/
RECORD: Rec_0303149 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 3
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli HB101
2.8 μM
MIC
PMID18676150;20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18676150/
RECORD: Rec_0326106 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 3
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Trichomonas vaginalis SS22
140 μM
LC50
PMID18676150;20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18676150/
RECORD: Rec_0338110 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
The 'X' at position 3 indicates Nal (3-[1-naphthyl]alanine).
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
HSV-1 | Vero cells
2.7 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperIn vitro activity of dermaseptin S1 derivatives against genital pathogens. | Savoia D, Donalisio M, Civra A, Salvadori S, Guerrini R. | APMIS. 2010 Sep 1;118(9):674-80. | DOI:10.1111/j.1600-0463.2010.02637.x | PMID:20718719 PMID20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718719/
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