Peptide Database

Peptide NameSLAY-screened peptide P322

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC120H157N29O29S

DescriptionStandard

        SLHYGPWHDIFNTPMSHYLW
    

Molecular Weight2501.77 Da

Isoelectric Point (pI)6.19

Net Charge (pH 7.0)-1.28

Net Charge (pH 7.4) -1.64

Charge Density (pH 7.0) -0.0640

GRAVY Index-0.51

Hydrophobic Moment 0.40

Boman Index0.24

Instability Index85.39

Aliphatic Index 58.50

Aromaticity 0.2500

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 13980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 897.80

LogP -3.66

H-bond Donors 31.0

H-bond Acceptors 32.0

Rotatable Bonds 69.0

Heavy Atoms 179.0

Ring Count 12.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0243384 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/