Peptide Database

Peptide NameCholecystokinin-25

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC135H206N38O40S2

DescriptionStandard

        IIKNLQNLDPSHRISDRDYMGWMDF
    

Molecular Weight3065.44 Da

Isoelectric Point (pI)5.36

Net Charge (pH 7.0)-1.15

Net Charge (pH 7.4) -1.41

Charge Density (pH 7.0) -0.0460

GRAVY Index-0.75

Hydrophobic Moment 0.53

Boman Index-0.12

Instability Index52.90

Aliphatic Index 78.00

Aromaticity 0.1200

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1286.38

LogP -10.66

H-bond Donors 44.0

H-bond Acceptors 42.0

Rotatable Bonds 101.0

Heavy Atoms 215.0

Ring Count 6.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0098205 VERIFIED: YES

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyCholecystokinin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other Mods19:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

TargetCCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Half-LifeMammalian: 20 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0156838 VERIFIED: YES

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyCholecystokinin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other Mods19:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

Half-LifeMammalian: 20 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0390887 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyGastrin/cholecystokinin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsTyr19 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide