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MYP_117290
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Basic Information
ChaC2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
32 amino acids
C143H226N38O44S7
Standard
Sequence
GIPCAESCVWIPPCTITALMGCSCKNNVCYNN
Physicochemical Analysis
3406.01 Da
5.96
-0.30
-0.59
-0.0093
0.44
0.25
0.24
40.77
73.12
0.0625
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1291.67
-15.01
48.0
51.0
102.0
232.0
6.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0392929 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Animal]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Hemolytic
human type A red blood cells
25 μM
HD50
PaperPubMed PMID: 22467870 PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0398457 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Animal]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Staphylococcus epidermidis
80 μM
MIC
PaperPubMed PMID: 22467870 PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0406158 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Animal]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Hemolytic
PaperPubMed PMID: 22467870 PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0418265 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
M at position 20 is oxidated
Bio-Activity Profile
Antimicrobial Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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