Peptide Database

Peptide NameTigerinin-2 (Frogs, amphibians, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC63H101N17O13S2

DescriptionStandard

        RVCFAIPLPICH
    

Molecular Weight1368.71 Da

Isoelectric Point (pI)8.08

Net Charge (pH 7.0)0.83

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0690

GRAVY Index1.31

Hydrophobic Moment 0.31

Boman Index0.38

Instability Index49.98

Aliphatic Index 130.00

Aromaticity 0.0833

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 456.42

LogP -1.11

H-bond Donors 17.0

H-bond Acceptors 17.0

Rotatable Bonds 38.0

Heavy Atoms 95.0

Ring Count 4.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0366911 VERIFIED: YES

Provenance & Taxonomy

OrganismRana tigerina [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-11

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetSaccharomyces cerevisiae ATCC 8530

Activity100 μg/mL

MethodMIC

RECORD: Rec_0376442 VERIFIED: NO