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MYP_117256
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Basic Information
Tigerinin-2 (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
12 amino acids
C63H101N17O13S2
Standard
Sequence
RVCFAIPLPICH
Physicochemical Analysis
1368.71 Da
8.08
0.83
0.55
0.0690
1.31
0.31
0.38
49.98
130.00
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
456.42
-1.11
17.0
17.0
38.0
95.0
4.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0218787 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus tigerinus [Animal]
Tigerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
3-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
29.0 μM
MIC
PaperK.P. Sai et al. / The Journal of Biological Chemistry 276 (2001) 2701-2707. Tigerinins: Novel Antimicrobial Peptides from the Indian Frog Rana tigerina Evidence URLhttps://www.uniprot.org/uniprotkb/P82652/entry
RECORD: Rec_0252127 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus tigerinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Saccharomyces cerevisiae ATCC 8530
100 μg/mL
MIC
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0255550 VERIFIED: YES
Provenance & Taxonomy
Rana tigerina [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus ATCC 8530
40 μg/mL
MIC
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0267738 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus tigerinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Bacillus subtilis
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0295732 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus tigerinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus MT 166
20 μg/mL
MIC
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
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