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MYP_117256
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Basic Information
Tigerinin-2 (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
12 amino acids
C63H101N17O13S2
Standard
Sequence
RVCFAIPLPICH
Physicochemical Analysis
1368.71 Da
8.08
0.83
0.55
0.0690
1.31
0.31
0.38
49.98
130.00
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
456.42
-1.11
17.0
17.0
38.0
95.0
4.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0080586 VERIFIED: YES
Provenance & Taxonomy
Rana tigerina [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
3-11
It contains one disulfide bond
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus ATCC 8530
40 μg/mL
MIC
PaperTigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina.
RECORD: Rec_0096121 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0116163 VERIFIED: YES
Provenance & Taxonomy
Rana tigerina [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0116730 VERIFIED: YES
Provenance & Taxonomy
Indian bullfrog [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-11
Bio-Activity Profile
Antimicrobial
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0127250 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus tigerinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Micrococcus luteus
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
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