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MYP_117225
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Basic Information
DENV Envelope glycoprotein (25-41)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C77H131N21O26S2
Standard
Sequence
LEHGSCVTTMAKDKPTL
Physicochemical Analysis
1831.12 Da
6.74
-0.16
-0.43
-0.0095
-0.29
0.34
-0.00
6.45
68.82
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
756.37
-8.56
27.0
29.0
60.0
126.0
2.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0307855 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID30508603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508603/
RECORD: Rec_0355168 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
DENV-1:inhibition of virus infection in Vero cells(58%±2.55% inhibition at 50 μM
10 μM
IC50
PMID30508603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508603/
RECORD: Rec_0384352 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
DENV-2 | Vero cells
10 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperIn vitro analysis of synthetic peptides in blocking the entry of dengue virus. | John AM, Jittmittraphap A, Chattanadee S, Alwin Prem Anand A, Shenbagarathai R, Leaungwutiwong P. | Virus Res. 2019 Jan 15;260:142-150. | DOI:10.1016/j.virusres.2018.11.016 | PMID:30508603 PMID30508603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508603/
RECORD: Rec_0385209 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
DENV-1 | Vero cells
10 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperIn vitro analysis of synthetic peptides in blocking the entry of dengue virus. | John AM, Jittmittraphap A, Chattanadee S, Alwin Prem Anand A, Shenbagarathai R, Leaungwutiwong P. | Virus Res. 2019 Jan 15;260:142-150. | DOI:10.1016/j.virusres.2018.11.016 | PMID:30508603 PMID30508603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508603/
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