‹ ›
MYP_117204
← PREVIOUS NEXT → BACK
Basic Information
Rugosin-C
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
37 amino acids
C168H285N45O49S3
Standard
Sequence
GILDSFKQFAKGVGKDLIKGAAQGVLSTMSCKLAKTC
Physicochemical Analysis
3815.53 Da
9.51
3.74
3.49
0.1010
0.25
0.68
0.12
22.76
89.73
0.0541
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1528.97
-16.23
55.0
56.0
135.0
265.0
2.0
38.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0114997 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Rugosin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
31-37
Bio-Activity Profile
Antimicrobial Antibacterial
PaperH-S. Won et al. / Biochimica et Biophysica Acta 1788 (2009) 1620-1629. Action mechanism and structural requirements of the antimicrobial peptides, gaegurins Evidence URLhttps://www.uniprot.org/uniprotkb/P80956/entry
RECORD: Rec_0180882 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0201576 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus 209P
PaperPubMed PMID: 7612013 PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/
RECORD: Rec_0295629 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 75.7%, E 0.0%, T 13.5%, C 10.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0305924 VERIFIED: NO
Provenance & Taxonomy
Glandirana rugosa [Animal]
Frog skin active peptide (FSAP)
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-positive Non-hemolytic Non-ribosomal
Gram-positive bacteria
Qualitative functional evidence
PMID7612013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7612013/; https://www.uniprot.org/uniprotkb/P80956/entry; https://bblserver.org.in/ampdb/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2