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MYP_117153
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Basic Information
M-lycotoxin-Ls3b (M-LCTX-Ls3b) (Lycocitin-2)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C89H153N25O24S
Standard
Sequence
GRLQAFLAKMKEIAAQTL
Physicochemical Analysis
1989.38 Da
9.99
1.76
1.55
0.0978
0.22
0.41
0.07
56.37
108.89
0.0556
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
815.67
-6.17
28.0
27.0
70.0
139.0
1.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0085615 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Cationic peptide 04 (cupiennin); 05 subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Pseudomonas aeruginosa
PMID14991689 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14991689/
RECORD: Rec_0089097 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa ATCC 27853
5.02-10.05 μM
MIC
PMID14991689 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14991689/
RECORD: Rec_0096543 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0096583 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus subtilis ATCC 6633
1.57-3.14 μM
MIC
PMID14991689 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14991689/
RECORD: Rec_0117429 VERIFIED: YES
Provenance & Taxonomy
Lycosa singoriensis [Animal]
Cationic peptide 04 (cupiennin); 05 subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Candida albicans
PMID14991689 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14991689/
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