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MYP_117144
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Basic Information
Hominicin (Bacteriocin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
21 amino acids
C99H163N21O29
Standard
Sequence
ITPATPFTPAIITEITAAVIA
Physicochemical Analysis
2111.48 Da
4.05
-1.24
-1.44
-0.0589
1.27
0.31
0.55
55.38
130.48
0.0476
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
757.40
-5.39
25.0
28.0
59.0
149.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0176581 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0208177 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus hominis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
MRSA
0.96 μg/mL
MIC
PaperCharacterization and structure identification of an antimicrobial peptide, hominicin, produced by Staphylococcus hominis MBBL 2-9
RECORD: Rec_0222386 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus hominis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
1-DmIle(N,N-dimethyl Ile)-I; 2,5,8,15-DHB(dehydrated threonine)-T;21-Dmp(N2, N2-dimethyl-1,2-propanediamine)-A
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
MRSA
0.96 μg/mL
MIC
PMID20654578 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20654578/
RECORD: Rec_0254495 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus hominis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
0.06 μg/mL
MIC
PaperCharacterization and structure identification of an antimicrobial peptide, hominicin, produced by Staphylococcus hominis MBBL 2-9
RECORD: Rec_0367492 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus hominis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
1-DmIle(N,N-dimethyl Ile)-I; 2,5,8,15-DHB(dehydrated threonine)-T;21-Dmp(N2, N2-dimethyl-1,2-propanediamine)-A
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PMID20654578 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20654578/
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