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MYP_116933
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Basic Information
Cyclo(Trp-Phe), Diketopiperazine (WF)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
2 amino acids
C20H21N3O3
Standard
Sequence
WF
Physicochemical Analysis
351.40 Da
5.53
-0.24
-0.44
-0.1200
0.95
0.66
1.00
5.00
0.00
1.0000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
108.21
1.85
4.0
3.0
7.0
26.0
3.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0198126 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
Escherichia coli
8 μg/mL
MIC
RECORD: Rec_0223123 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID32806659 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32806659/
RECORD: Rec_0384009 VERIFIED: YES
Provenance & Taxonomy
Euphausia superba [Animal]
Angiotensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
Angiotensin-I converting enzyme
318±50 μg/mL
IC50
RECORD: Rec_0410807 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Staphylococcus aureus
4 μg/mL
MIC
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