Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 2.1

Function Ontology

Annotation / Sequence feature ▸ Nuclear export signal

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC174H291N51O55S7

DescriptionStandard

        TIINVKCTSPKQCSKPCKELYGSSAGAKCMNGKCKCYNN
    

Molecular Weight4201.94 Da

Isoelectric Point (pI)9.22

Net Charge (pH 7.0)5.33

Net Charge (pH 7.4) 5.04

Charge Density (pH 7.0) 0.1367

GRAVY Index-0.57

Hydrophobic Moment 0.56

Boman Index-0.14

Instability Index31.81

Aliphatic Index 42.56

Aromaticity 0.0513

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1748.27

LogP -23.94

H-bond Donors 65.0

H-bond Acceptors 68.0

Rotatable Bonds 143.0

Heavy Atoms 287.0

Ring Count 4.0

Amide Bonds 43.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0011115 VERIFIED: NO

Provenance & Taxonomy

OrganismCentruroides noxius [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Toxin

RECORD: Rec_0324690 VERIFIED: YES

Provenance & Taxonomy

OrganismCentruroides noxius [Animal]

FamilyPotassium channel inhibitor family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide7-29; 13-34; 17-36

Bio-Activity Profile

Function

Toxin Venom Potassium channel inhibitor family Ion channel inhibitor Pathogenesis-associated Host defense