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MYP_116827
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Basic Information
GnRH-III(N-Me-4Ser,8Lys(DaudAoa))
Anticancer
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Reproductive neuropeptide
Reproductive biology ▸ Reproductive modulation
Standard
9 amino acids
C54H68N16O13
Standard
Sequence
HWSHDWKPG
Physicochemical Analysis
1149.22 Da
6.92
-0.07
-0.37
-0.0073
-2.04
0.34
-0.13
-2.69
0.00
0.2222
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
459.82
-2.61
16.0
15.0
31.0
83.0
7.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012881 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GnRH-III
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
K(8)=(Dau=Aoa);S(4)=-N-Me
Bio-Activity Profile
Anticancer
LNCaP
14.1 ± 1.3 μM
IC50
Trypsin, α-chymotrypsin, and pepsin: All bioconjugates showed high stability in the presence of pepsin even after 25 h of incubation, as no proteolytic fragmentswere identified by LC-MS
PaperManea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G. Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4. Bioconjug Chem. 2011 Jul 20;22(7):1320-9. PMID:21668011 https://pubmed.ncbi.nlm.nih.gov/21668011/ PMID21668011 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21668011/
RECORD: Rec_0040326 VERIFIED: YES
Provenance & Taxonomy
Petromyzon marinus [Animal]
GnRH
7757
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Reproductive neuropeptide
PMID17254668 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17254668/
RECORD: Rec_0164577 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GnRH-III
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
K(8)=(Dau=Aoa)
Bio-Activity Profile
Anticancer
HT-29
27.8 ± 5.4 μM
IC50
Trypsin, α-chymotrypsin, and pepsin: All bioconjugates showed high stability in the presence of pepsin even after 24 h of incubation, as no proteolytic fragmentswere identified by LC-MS
PaperManea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G. Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4. Bioconjug Chem. 2011 Jul 20;22(7):1320-9. PMID:21668011 https://pubmed.ncbi.nlm.nih.gov/21668011/ PMID21668011 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21668011/
RECORD: Rec_0277066 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GnRH-III
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
K(8)=(Dau=Aoa);S(4)=-N-Me
Bio-Activity Profile
Anticancer
HT-29
>50 μM
IC50
Trypsin, α-chymotrypsin, and pepsin: All bioconjugates showed high stability in the presence of pepsin even after 25 h of incubation, as no proteolytic fragmentswere identified by LC-MS
PaperManea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G. Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4. Bioconjug Chem. 2011 Jul 20;22(7):1320-9. PMID:21668011 https://pubmed.ncbi.nlm.nih.gov/21668011/ PMID21668011 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21668011/
RECORD: Rec_0315496 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GnRH-III
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
K(8)=(Dau=Aoa)
Bio-Activity Profile
Anticancer
LNCaP
6.1 ± 2.1 μM
IC50
Trypsin, α-chymotrypsin, and pepsin: All bioconjugates showed high stability in the presence of pepsin even after 24 h of incubation, as no proteolytic fragmentswere identified by LC-MS
PaperManea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G. Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4. Bioconjug Chem. 2011 Jul 20;22(7):1320-9. PMID:21668011 https://pubmed.ncbi.nlm.nih.gov/21668011/ PMID21668011 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21668011/
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