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MYP_116819
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Basic Information
Chromogranin-A fragment 5
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Hormonal / Endocrine ▸ Hormone peptide
Hormonal / Endocrine ▸ Secretory pathway peptide ▸ Secretory granule peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Standard
17 amino acids
C82H132N24O30S
Standard
Sequence
LEGEDDPDRSMKLSFRA
Physicochemical Analysis
1966.13 Da
4.44
-2.23
-2.44
-0.1313
-1.17
0.59
-0.35
28.29
51.76
0.0588
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
896.91
-9.81
31.0
29.0
67.0
137.0
2.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0039178 VERIFIED: NO
Provenance & Taxonomy
Rattus norvegicus [Animal]
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
RECORD: Rec_0288603 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0300911 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
CMGA
10116
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
10:Phosphoserine; 11:Methionine sulfoxide
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasoconstrictor Metabolic regulation Physiological regulation Myotropic Receptor modulation Immunomodulatory
Mammalian: 5.5 hour; Yeast: 3 min; E. coli: 2 min
PaperNeurotoxin-induced neuropeptide perturbations in striatum of neonatal rats PMID23410195 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23410195/
RECORD: Rec_0308399 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Chromogranin/secretogranin
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Secretory granule peptide Neuropeptide precursor
PaperNeurotoxin-induced neuropeptide perturbations in striatum of neonatal rats PMID23410195 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23410195/
RECORD: Rec_0349773 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
CMGA
10116
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
10:Phosphoserine; 11:Methionine sulfoxide
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasoconstrictor Metabolic regulation Physiological regulation Myotropic Receptor modulation Immunomodulatory
inhibits catecholamine release from chromaffin cells
Mammalian: 5.5 hour; Yeast: 3 min; E. coli: 2 min
PaperNeurotoxin-induced neuropeptide perturbations in striatum of neonatal rats PMID23410195 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23410195/