Peptide Database

Peptide NameSLAY-screened peptide P4118

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC99H151N33O29S4

DescriptionStandard

        GNSRRTMHSNCCLWHYDCLV
    

Molecular Weight2395.72 Da

Isoelectric Point (pI)7.98

Net Charge (pH 7.0)0.90

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0452

GRAVY Index-0.48

Hydrophobic Moment 0.36

Boman Index-0.12

Instability Index147.47

Aliphatic Index 53.50

Aromaticity 0.1000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1017.57

LogP -11.75

H-bond Donors 40.0

H-bond Acceptors 36.0

Rotatable Bonds 75.0

Heavy Atoms 165.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0203473 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/