Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length488 amino acids

Chemical FormulaC2474H3871N619O716S18

DescriptionStandard

        MESEKILVLCGCFLLWNPLIQSTQLYPGIKVRITQKGLDYGMQAGMEAIELIVKKNGIPDFKGSESLEFLKVDYVDYNFSNIKINTFSFPNISLTPVSGTGVKVLSNHGSTNVSMAWEVTSPLFRDEGGAALFLAEIFFSGLVNLSRSDTGHPTMKLEDCYIRVGHAHISFSGEFSVLYNSFAEPMEKPILKNLNKKLCPIIMDRFEDINANISSLEVVTKFGEDILLDYSLLEPPEITQSSIDLNLKGTFYQVGNLTDPPFQPVPFTLPDRSDSMLYIGISEYFLRSAAFTYFLTGAFNITLTTKELSKHLIQNPQGIGSLFSQIAELYIMTQPLMMRVLTTEPPVVSLEPNNFTLNIPGSVVMLTKPKNATEEAIVSMDFVASTDVGLAILGQKLICSLSLNRFRLSGPESNRSSIEVLRFENILSSILHFGVFPLANARLQQGFPLPNPHQISLVKSDIEVHKGFLLVSTDLRYDPLWKKQHFGG
    

Molecular Weight54319.09 Da

Isoelectric Point (pI)5.48

Net Charge (pH 7.0)-9.70

Net Charge (pH 7.4) -10.56

Charge Density (pH 7.0) -0.0199

GRAVY Index0.08

Hydrophobic Moment 0.62

Boman Index0.15

Instability Index39.74

Aliphatic Index 100.04

Aromaticity 0.0984

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0069414 VERIFIED: NO

Provenance & Taxonomy

OrganismPhascolarctos cinereus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria