‹ ›
MYP_116714
← PREVIOUS NEXT → BACK
Basic Information
Ilamycin D
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
7 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXLXAXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0072172 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
noncanonical residue-containing cyclic peptide [Modified]
None
None
X(1)=Pre-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(7)=METH-Leu
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
HeLa
7.1 μM
IC50
PaperBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. PMID: 28855504. PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0073772 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
noncanonical residue-containing cyclic peptide [Modified]
None
None
X(1)=Pre-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(7)=METH-Leu
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MCF-7
4.5 μM
IC50
PaperBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. PMID: 28855504. PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0074123 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
noncanonical residue-containing cyclic peptide [Modified]
None
None
X(1)=Pre-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(7)=METH-Leu
Bio-Activity Profile
Antimicrobial Anticancer
HepG2
3.2 μM
IC50
PaperBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. PMID: 28855504. PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0074429 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
noncanonical residue-containing cyclic peptide [Modified]
None
None
X(1)=Pre-OH-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(8)=METH-Leu
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
A549
50 μM
IC50
PaperBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. PMID: 28855504. PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0077562 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus SCSIO ZH16 [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
noncanonical residue-containing cyclic peptide [Modified]
unspecified non-canonical residue at 1,2,4,6,7
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus MR
124.8 μM
MIC
PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
FIRST PREV 1 ... 5 6 7 8 9 ... 36 NEXT LAST
Showing 5 records · Page 7 of 36