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MYP_116714
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Basic Information
Ilamycin D
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
7 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXLXAXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0060359 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus SCSIO ZH16 [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
noncanonical residue-containing cyclic peptide [Modified]
unspecified non-canonical residue at 1,2,4,6,7
Bio-Activity Profile
Antimicrobial Antibacterial Cytotoxic Anticancer
Human cervical carcinoma HeLa
50 μM
IC50
PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0061521 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus SCSIO ZH16 [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
noncanonical residue-containing cyclic peptide [Modified]
unspecified non-canonical residue at 1,2,4,6,7
Bio-Activity Profile
Antimicrobial Antibacterial
Mycobacterium tuberculosis H37Rv
0.0098 μM
MIC
PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0065628 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
noncanonical residue-containing cyclic peptide [Modified]
None
None
X(1)=Pre-OH-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(8)=METH-Leu
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
A549
13.8 μM
IC50
PaperBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. PMID: 28855504. PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0066417 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
noncanonical residue-containing cyclic peptide [Modified]
None
None
X(1)=Pre-OH-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(7)=METH-Leu
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
HeLa
3.3 μM
IC50
PaperBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. PMID: 28855504. PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0070675 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus [Bacterium]
Structure & Mods
cyclic peptide [Cyclic]
noncanonical residue-containing cyclic peptide [Modified]
None
None
X(1)=Pre-OH-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=OH-METH-Leu; X(6)=N-Tyr; X(8)=METH-Leu
Bio-Activity Profile
Antimicrobial Anticancer
CNE2
6.8 μM
IC50
PaperBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. PMID: 28855504. PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
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