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MYP_116714
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Basic Information
Ilamycin D
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
7 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXLXAXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0391836 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus SCSIO ZH16 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 1,2,4,6,7
Bio-Activity Profile
Antimicrobial Antibacterial
Human breast adenocarcinoma MCF-7
3.9 μM
IC50
PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0397926 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus SCSIO ZH16 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 1,2,4,6,7
Bio-Activity Profile
Antimicrobial Antibacterial
Acinetobacter baumannii ATCC 19606
124.8 μM
MIC
PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0398379 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus SCSIO ZH16 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 1,2,4,6,7
Bio-Activity Profile
Cytotoxic
Human hepatocyte cells HL-7702 (L02)
7.4 μM
IC50
PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0400177 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus SCSIO ZH16 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 1,2,4,6,7
Bio-Activity Profile
Antimicrobial Antibacterial
Mycobacterium tuberculosis H37Rv
98.9 μM
MIC
PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0400399 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus [Bacterium]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X(1)=Pre-OH-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=OH-METH-Leu; X(6)=N-Tyr; X(8)=METH-Leu
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
7.1 μM
IC50
PaperBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. PMID: 28855504. PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
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