‹ ›
MYP_116714
← PREVIOUS NEXT → BACK
Basic Information
Ilamycin D
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
7 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXLXAXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0369494 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus SCSIO ZH16 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 1,2,4,6,7
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 29213
122.9 μM
MIC
PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0371173 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus [Bacterium]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X(1)=Pre-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(7)=METH-Leu
Bio-Activity Profile
Antimicrobial Anticancer
A549
50 μM
IC50
PaperBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. PMID: 28855504. PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0371654 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus [Bacterium]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X(1)=Pre-OH-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(8)=METH-Leu
Bio-Activity Profile
Antimicrobial Anticancer
HepG2
3.2 μM
IC50
PaperBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. PMID: 28855504. PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0376679 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus SCSIO ZH16 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 1,2,4,6,7
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis ATCC 29212
126.5 μM
MIC
PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
RECORD: Rec_0380192 VERIFIED: YES
Provenance & Taxonomy
Streptomyces atratus [Bacterium]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X(1)=Pre-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(7)=METH-Leu
Bio-Activity Profile
Antimicrobial Anticancer
CNE2
50 μM
IC50
PaperBiosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun. 2017 Aug 30;8(1):391. doi: 10.1038/s41467-017-00419-5. PMID: 28855504. PMID28855504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28855504/
FIRST PREV 1 ... 29 30 31 32 33 ... 36 NEXT LAST
Showing 5 records on this page · Page 31 of 36