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MYP_116653
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Basic Information
GI-20D
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Filovirus ▸ Anti-Ebola virus
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C114H194N34O27
Standard
Sequence
GIKEFKRIVQRIKDFLRNLV
Physicochemical Analysis
2472.97 Da
11.00
3.76
3.55
0.1880
-0.23
0.99
-0.20
13.34
126.50
0.1000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1040.76
-6.07
37.0
31.0
89.0
175.0
2.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001651 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PMID32252021 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32252021/
RECORD: Rec_0032047 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
Bio-Activity Profile
Antiviral Entry inhibition
inhibition of viral infection in primary macrophages
2.2 μM
IC50
PaperEngineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection. | Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K. | iScience. 2020 Apr 24;23(4):100999. | DOI:10.1016/j.isci.2020.100999 | PMID:32252021 PMID32252021 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32252021/
RECORD: Rec_0042087 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
18.9 μM
Cytotoxicity
PMID34959645 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34959645/
RECORD: Rec_0042548 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Bos taurus [Animal]
Cathelicidin
9606,9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Multifunction
CEM-SS
1.08 μM
IC50
PaperAnti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins. PMID18591279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18591279/
RECORD: Rec_0056382 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Derivative of [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Spermicidal
Acinetobacter baumannii B28-16
8 μM
MIC
PaperAnti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins.
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