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MYP_116631
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Basic Information
Gallidermin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
22 amino acids
C99H153N25O30S4
Standard
Sequence
IASKFLCTPGCAKTGSFNSYCC
Physicochemical Analysis
2301.68 Da
8.52
1.72
1.45
0.0781
0.40
0.30
0.19
20.50
44.55
0.1364
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
882.14
-11.50
35.0
36.0
71.0
158.0
4.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0406030 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus gallinarum [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Gallidermin differs from StT (a natural variant of this peptide) only by one base in the nucleotide sequence for the leader sequence. However, there is no difference at the amino acid level (Furmanek B et al. 1999 J Appl Microbiol 87: 856-866). Thus, they are treated as identical peptide in this database. Chemical modification: Gallidermin contains four thioether rings (S3-C7, T8-C11, S16-C21, and S19-C22) and dehydrated T14
Bio-Activity Profile
Antimicrobial
Micrococcus luteus 15957 or ATCC 9341
0.25-0.5 μg/mL
MIC
PaperGallidermin: a new lanthionine-containing polypeptide antibiotic
RECORD: Rec_0414693 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus gallinarum Tu3928,Staphylococcus cohnii T [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus pyogenes ATCC 8668
1 μg/mL
MIC
PMID3181159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3181159/
RECORD: Rec_0414911 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus gallinarum Tu3928,Staphylococcus cohnii T [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Corynebacterium xerosis ATCC 9755
1 μg/mL
MIC
PMID3181159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3181159/
RECORD: Rec_0425230 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus gallinarum Tu3928,Staphylococcus cohnii T [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus faecalis ATCC 29212
64 μg/mL
MIC
PMID3181159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3181159/
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