Peptide Database

Peptide Namehuman GIP(3-42)NH2

Function Ontology

Hormonal / Endocrine ▸ Hormonal activity

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Receptor modulation ▸ Antagonist

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC214H324N58O63S

DescriptionStandard

        EGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ
    

Molecular Weight4749.28 Da

Isoelectric Point (pI)7.01

Net Charge (pH 7.0)0.01

Net Charge (pH 7.4) -0.27

Charge Density (pH 7.0) 0.0002

GRAVY Index-0.85

Hydrophobic Moment 0.36

Boman Index-0.08

Instability Index28.57

Aliphatic Index 70.75

Aromaticity 0.1250

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2006.54

LogP -18.05

H-bond Donors 67.0

H-bond Acceptors 66.0

Rotatable Bonds 162.0

Heavy Atoms 336.0

Ring Count 9.0

Amide Bonds 46.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0279840 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-Termamidated

Other ModsC-terminal amidation

Bio-Activity Profile

Function

Receptor antagonist Antidiabetic Hormonal activity

TargetGIP receptor (Human)

Activity92-731 nM

MethodIC50