Peptide Database

Peptide NameGnRH-III(4Lys(Ac),8Lys(DaudAoa))

Function Ontology

Anticancer

Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC57H75N17O12

DescriptionStandard

        HWKHDWKPG
    

Molecular Weight1190.31 Da

Isoelectric Point (pI)8.61

Net Charge (pH 7.0)0.93

Net Charge (pH 7.4) 0.63

Charge Density (pH 7.0) 0.1037

GRAVY Index-2.39

Hydrophobic Moment 0.37

Boman Index-0.28

Instability Index-2.69

Aliphatic Index 0.00

Aromaticity 0.2222

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 465.61

LogP -1.47

H-bond Donors 16.0

H-bond Acceptors 15.0

Rotatable Bonds 34.0

Heavy Atoms 86.0

Ring Count 7.0

Amide Bonds 8.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0395648 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyGnRH-III

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other ModsK(8)=(Dau=Aoa);K(4)=-Ac

Bio-Activity Profile

Function

Anticancer

TargetHT-29

Activity7.4 ± 2.6 μM

MethodIC50

Half-LifeTrypsin, α-chymotrypsin, and pepsin: All bioconjugates showed high stability in the presence of pepsin even after 26 h of incubation, as no proteolytic fragmentswere identified by LC-MS

PaperManea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G. Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4. Bioconjug Chem. 2011 Jul 20;22(7):1320-9. PMID:21668011 https://pubmed.ncbi.nlm.nih.gov/21668011/ PMID21668011 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21668011/

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