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MYP_116494
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Basic Information
GnRH-III(4Lys(Ac),8Lys(DaudAoa))
Anticancer
Standard
9 amino acids
C57H75N17O12
Standard
Sequence
HWKHDWKPG
Physicochemical Analysis
1190.31 Da
8.61
0.93
0.63
0.1037
-2.39
0.37
-0.28
-2.69
0.00
0.2222
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
465.61
-1.47
16.0
15.0
34.0
86.0
7.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0066108 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GnRH-III
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
K(8)=(Dau=Aoa)
Bio-Activity Profile
Anticancer
HT-29
8.1 ± 2.6 μM
IC50
Trypsin, α-chymotrypsin, and pepsin: All bioconjugates showed high stability in the presence of pepsin even after 27 h of incubation, as no proteolytic fragmentswere identified by LC-MS
PaperManea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G. Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4. Bioconjug Chem. 2011 Jul 20;22(7):1320-9. PMID:21668011 https://pubmed.ncbi.nlm.nih.gov/21668011/ PMID21668011 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21668011/
RECORD: Rec_0132593 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GnRH-III
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
K(8)=(Dau=Aoa)
Bio-Activity Profile
Anticancer
LNCaP
5.1 ± 0.4 μM
IC50
Trypsin, α-chymotrypsin, and pepsin: All bioconjugates showed high stability in the presence of pepsin even after 27 h of incubation, as no proteolytic fragmentswere identified by LC-MS
PaperManea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G. Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4. Bioconjug Chem. 2011 Jul 20;22(7):1320-9. PMID:21668011 https://pubmed.ncbi.nlm.nih.gov/21668011/ PMID21668011 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21668011/
RECORD: Rec_0253581 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GnRH-III
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
K(8)=(Dau=Aoa);K(4)=-Ac
Bio-Activity Profile
Anticancer
MCF-7
3.1 ± 1.7 μM
IC50
Trypsin, α-chymotrypsin, and pepsin: All bioconjugates showed high stability in the presence of pepsin even after 26 h of incubation, as no proteolytic fragmentswere identified by LC-MS
PaperManea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G. Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4. Bioconjug Chem. 2011 Jul 20;22(7):1320-9. PMID:21668011 https://pubmed.ncbi.nlm.nih.gov/21668011/ PMID21668011 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21668011/
RECORD: Rec_0262158 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GnRH-III
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
K(8)=(Dau=Aoa)
Bio-Activity Profile
Anticancer
MCF-7
2.6 ± 0.8 μM
IC50
Trypsin, α-chymotrypsin, and pepsin: All bioconjugates showed high stability in the presence of pepsin even after 27 h of incubation, as no proteolytic fragmentswere identified by LC-MS
PaperManea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G. Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4. Bioconjug Chem. 2011 Jul 20;22(7):1320-9. PMID:21668011 https://pubmed.ncbi.nlm.nih.gov/21668011/ PMID21668011 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21668011/
RECORD: Rec_0367837 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GnRH-III
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
K(8)=(Dau=Aoa);K(4)=-Ac
Bio-Activity Profile
Anticancer
LNCaP
3.6 ± 2.9 μM
IC50
Trypsin, α-chymotrypsin, and pepsin: All bioconjugates showed high stability in the presence of pepsin even after 26 h of incubation, as no proteolytic fragmentswere identified by LC-MS
PaperManea M, Leurs U, Orbán E, Baranyai Z, Öhlschläger P, Marquardt A, Schulcz Á, Tejeda M, Kapuvári B, Tóvári J, Mezo G. Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4. Bioconjug Chem. 2011 Jul 20;22(7):1320-9. PMID:21668011 https://pubmed.ncbi.nlm.nih.gov/21668011/ PMID21668011 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21668011/
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