Peptide Database

Peptide NameAdipokinetic prohormone

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length46 amino acids

Chemical FormulaC222H356N66O70S4

DescriptionStandard

        QLTFTSSWGGKRAMTNSISCRNDEAIAAIYKAIQNEAERFIMCQKN
    

Molecular Weight5197.86 Da

Isoelectric Point (pI)8.82

Net Charge (pH 7.0)1.75

Net Charge (pH 7.4) 1.50

Charge Density (pH 7.0) 0.0380

GRAVY Index-0.45

Hydrophobic Moment 0.65

Boman Index-0.08

Instability Index26.56

Aliphatic Index 63.91

Aromaticity 0.0870

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2265.04

LogP -26.95

H-bond Donors 81.0

H-bond Acceptors 76.0

Rotatable Bonds 178.0

Heavy Atoms 362.0

Ring Count 5.0

Amide Bonds 52.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0141089 VERIFIED: YES

Provenance & Taxonomy

OrganismManduca sexta [Animal]

FamilyAdipokinetic prohormone

Tax ID7130

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Other Mods9:Glycine amide

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0227802 VERIFIED: NO

Provenance & Taxonomy

OrganismManduca sexta [Animal]

FamilyAKH/HRTH/RPCH

Tax ID7130

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

Other ModsTrp8 Amidation

Bio-Activity Profile

Function

Neuropeptide Invertebrate neurohormone Metabolic

RECORD: Rec_0301084 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/