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MYP_116379
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Basic Information
Brevinin-2ISb
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
33 amino acids
C150H253N39O48S2
Standard
Sequence
SFLTTFKDLAIKAAKSAGQSVLSTLSCKLSNTC
Physicochemical Analysis
3434.98 Da
9.30
2.44
2.19
0.0739
0.35
0.54
0.12
24.36
91.82
0.0606
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1424.38
-18.49
53.0
53.0
117.0
239.0
2.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002891 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
MRSA
>100 μM
MIC
PaperIdentification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae
RECORD: Rec_0066030 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 51.5%, E 0.0%, T 21.2%, C 27.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0105986 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
6.3 μM
MIC
RECORD: Rec_0112148 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
12.5 μM
MIC
PaperE. Iwakoshi-Ukena et al. / Peptides 32 (2011) 670-676. Identification and characterization of antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae PMID21193000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21193000/
RECORD: Rec_0128004 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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