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MYP_116335
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Basic Information
VG
Antiviral
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
42 amino acids
C193H323N55O66S
Standard
Sequence
VALDPIDISIVLNKAKSDLEESKEWIRRSNGKLDSIGSGSGC
Physicochemical Analysis
4502.02 Da
5.05
-1.27
-1.51
-0.0302
-0.32
0.61
-0.05
43.21
102.14
0.0238
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1980.19
-23.04
70.0
66.0
157.0
315.0
3.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0388435 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
0.001 μM
IC50
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/
RECORD: Rec_0426699 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Human parainfluenza virus 3 (HPIV-3) | Vero cells
0.28±0.247 μM
IC90
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperBroad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides | Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A | Sci Rep. 2017 Mar 8;7:43610. | DOI:10.1038/srep43610 | PMID:28344321 PMID28344321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28344321/